In the evolving landscape of precision oncology, genomic characterization of tumor has become crucial in order to move toward a molecular-based therapy for the vast majority of cancers. Recently, translational research has offered new perspectives in systemic cancer treatment thanks to the identification of novel oncogenic targets and the development of new targeted therapies, followed by the latest applications of genomic sequencing. Simultaneously, next-generation sequencing NGS has expanded its accessibility, being incorporated into clinical studies at the time of the initial screening, disease progression, and often in longitudinal monitoring of molecular changes. Consequently, new potentially targetable molecular alterations have been identified in several different types of tumors, leading to the development of tumor-agnostic treatments. Being highly selective for specific molecular alterations, these drugs are active against different subtypes of oncogene-addicted cancers. In this article, we critically review the clinical studies responsible for FDA approval and the most recently updated results. We then discuss the benefits and limitations of these new methodological approaches, paying particular attention to the largest precision medicine master protocol, NCI-MATCH. Among the benefits, there are the increased chances of offering targeted therapies for patients with specific alterations identified in different types of tumors.
SIAM Journal on Computing
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Task-Agnostic Online Reinforcement Learning with an Infinite Mixture of arXiv – CS – Artificial Intelligence Pub Date: , DOI: arxiv
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We hope this content on epidemiology, disease modeling, pandemics and vaccines will help in the rapid fight against this global problem. Click on title above or here to access this collection. We study the learnability of several fundamental concept classes in the agnostic learning framework of [D. Haussler, Inform.
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The New York dating app, which is now available here, wants people to connect deeply and so it encourages them to meet in person and not stay online, says. The hardened swipers of dating apps such as Tinder may be too jaded to notice that a New York alternative, Hinge, is now in Ireland. It launched here in April, and its founder says Hinge is the fastest-growing dating app in Ireland. Although he provides no figures, he says that compared with other markets where Hinge recently launched — Scandinavia, the Netherlands — the uptake in Ireland is twice as high.
Second, we analyzed behavioral data from a national online dating community. which Christian men communicate with Christian rather than atheist/agnostic.
Agnosticism is the view that the existence of God , of the divine or the supernatural is unknown or unknowable. The English biologist Thomas Henry Huxley coined the word agnostic in , and said"It simply means that a man shall not say he knows or believes that which he has no scientific grounds for professing to know or believe. Agnosticism is the doctrine or tenet of agnostics with regard to the existence of anything beyond and behind material phenomena or to knowledge of a First Cause or God,  and is not a religion.
Agnosticism is of the essence of science, whether ancient or modern. It simply means that a man shall not say he knows or believes that which he has no scientific grounds for professing to know or believe. Consequently, agnosticism puts aside not only the greater part of popular theology, but also the greater part of anti-theology. On the whole, the “bosh” of heterodoxy is more offensive to me than that of orthodoxy, because heterodoxy professes to be guided by reason and science, and orthodoxy does not.
That which Agnostics deny and repudiate, as immoral, is the contrary doctrine, that there are propositions which men ought to believe, without logically satisfactory evidence; and that reprobation ought to attach to the profession of disbelief in such inadequately supported propositions. Agnosticism, in fact, is not a creed, but a method, the essence of which lies in the rigorous application of a single principle Positively the principle may be expressed: In matters of the intellect, follow your reason as far as it will take you, without regard to any other consideration.
And negatively: In matters of the intellect do not pretend that conclusions are certain which are not demonstrated or demonstrable.
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Implementation of the agnostic approach, however, has not yet been fully achieved. In particular, agnostic mapping of pre-mRNA splice sites has not been demonstrated. The present study pursued dual goals: 1 to advance mRNA-seq bioinformatics toward unbiased transcriptome capture and 2 to demonstrate its potential for discovery in neuroscience by applying the approach to an in vivo model of neurological disease.
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